Trauma & PTSD

Articles

Acupuncture for Posttraumatic Stress Disorder: A Randomized Controlled Pilot Trial

This article, by Hollifield, Michael; Sinclair-Lian, Nityamo; Warner, Teddy D.; Hammerschlag, Richard, was published in The Journal of Nervous and Mental Disease. Volume 195, Number 6 (June 2007). (Link is to full article.)

The purpose of the study was to evaluate the potential efficacy and acceptability of acupuncture for posttraumatic stress disorder (PTSD). People diagnosed with PTSD were randomized to either an empirically developed acupuncture treatment (ACU), a group cognitive-behavioral therapy (CBT), or a wait-list control (WLC). The primary outcome measure was self-reported PTSD

Posttraumatic Stress Disorder, Depression, and Somatic Symptoms in U.S. Mien Patients

Moore L.J., Boehlein J.K. (1991). Journal of Nervous and Mental Disease, 179:728-733.

This report describes treatment over a period of 6 years of Mien refugees from highland Laos in the Indochinese Psychiatric Program of the Oregon Health Sciences University (Portland, OR). The medical and psychiatric problems of 84 patients were presented through somatic symptoms such as headache, dizziness, or musculoskeletal pain. Primary care medical problems were identified and treated, with the major focus on the two most common psychiatric diagnoses: major depression and posttraumatic stress disorder.

Refugee trauma versus torture trauma: a retrospective controlled cohort study of Tibetan refugees

Holtz T.H. (1998). Journal of Nervous & Mental Disease, 186(1):24-34.

A retrospective cohort study of 35 refugee Tibetan nuns and lay students who were arrested and tortured in Tibet matched with 35 controls who were not arrested or tortured was carried out in India. Subjects were administered the Hopkins Checklist-25, evaluating anxiety symptoms, affective disturbances, somatic complaints, and social impairment. The prevalence of symptom scores in the clinical range for both cohorts was 41.4% for anxiety symptoms and 14.3% for depressive symptoms.

Trauma experiences, posttraumatic stress, dissociation, and depression in Cambodian refugees

This study, of Cambodian refugees who have been resettled in the United States, examines the levels of trauma and psychiatric symptoms and to determine the relationship between the amount of trauma experienced and subsequent psychiatric symptoms. Subjects experienced multiple and severe traumas and showed high levels of all symptoms measured. Forty-three (86%) of the subjects met DSM-III-R criteria for posttraumatic stress disorder, 48 (96%) had high dissociation scores, and 40 (80%) could be classified as suffering from clinical depression.

Webinars

New Information on the Neuroscience of PTSD & Depression: How It Affects Torture Treatment and Outcomes

Rating: 

Average: 3.7 (3 votes)

Date: 

Wednesday, 25 April 2012

Description

The brain is very sensitive to the environment. It responds to both internal and external environment, including trauma. The brain is capable of rapid physiological and affective changes, depending upon the heredity and stress (genes & environment). All of us who treat patients need to know how the brain interacts with our work. This information helps us in understanding how therapy affects the outcome and why medications act differently on various symptoms of PTSD and depression and need to be tailored to each individual. Current information is based on newer study methods including MRI and fMRI, animal studies including “knockout mice”, DNA, micro assays, viral-medicated gene transfer, among others. The presentation provides information to help us understand why some individuals, as compared to others, suffer more severe reactions to trauma. The presentation also helps us understand varying reactions to treatment and the interactive effects of psychiatric medications and psychotherapy. In the future, we should have a better idea of what medicines will work for a particular individual prior to treatment.

Presenter

Dr. David Kinzie is Professor of Psychiatry, clinician, and researcher at the Oregon Health & Science University, where he founded the Intercultural Psychiatric Program (IPP) in 1977. He currently treats survivors of torture from Bosnia, Somalia, Ethiopia, Vietnam, and Cambodia in the Torture Treatment Center of Oregon, a part of the IPP. Dr. Kinzie is a distinguished fellow in the American College of Psychiatrists and has published widely on the effects of trauma and torture on refugees and immigrants, effective treatment and outcomes.

References/Bibliography for further research

J. David Kinzie, M.D., F.A.C. Psych

  1. Alsene KM, Bakshi VP.  Pharmacological stimulation of locus coeruleus reveals a new antipsychotic-responsive pathway for deficient sensorimotor gating.  Neuropsychopharmacology 2011; 8: 1656-67. Available for Free
  2. Bowirrat A et al.  Neuro-psychopharmacogentics and Neurological Antecedents of Posttraumatic Stress Disorder:  Unlocking the Mysteries of resilience and Vulnerability.  Curr Neuropharmacol 2010; 8:  335-358. Available for Free
  3. Brodman D et al.  The Implications of Neurocognitive Deficits in Posttraumatic Stress Disorder.  Psychiatric Annals 2011; 41: 8.
  4. Choi DC et al.  Pharmacological enhancement of behavioral therapy:  focus on posttraumatic stress disorder.  Curr Top Behav Neurosci 2010; 2:279-99. Available for Purchase
  5. Goosens KA.  Hippocampal regulation of aversive memories.  Curr Opin Neurobiol 2011; 21: 460-6. Available for Free
  6. Kaplan A.  Psychiatric Pharmacogenomics.  Psychiatric Times 2011; XXVIII, No. 12:  1-6.
  7. Kim MJ et al.  The structural and functional connectivity of the amygdale: from normal emotion to pathological anxiety.  Behav Brain Res 2011; 223: 403-10. Available for Purchase
  8. Kolassa IT et al.  Association study of trauma load and SLC6A4 promoter polymorphism in posttraumatic stress disorder: evidence from survivors of the Rwandan genocide.  J Clin Psychiatry 2010; 71: 543-7. Available for Purchase
  9. Kuzelova H et al.  The serotonin transporter gene (5-HTT) variant and psychiatric disorders:  review of current literature.  Neuro Endocrinol Lett 2010; 31: 4 – 10.
  10. Lin KM.  Cultural and Ethnic Issues in Psychopharmacology.  Psychiatric Times 2012; March, 30 – 33. Available for Free
  11. Norberg MM et al.  A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy.  Bio Psychiatry 2008; 63: 1118-26. Available for Free
  12. Quide Y et al.  Differences between effects of psychological versus pharmacological treatments on functional and morphological brain alterations in anxiety disorders and major depressive disorder: a systematic review.  Neurosci Biobehav rev 2012; 36: 626-44. Available for Purchase
  13. Sherin JE, Nemeroff CB.  Post-traumatic stress disorder: the neurobiological impact of psychological trauma.  Dialogues Clin Neurosci 2011; 13: 263-278. Available for Free
  14. Xie P et al.  Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.  Arch Gen Psychiatry 2009; 66: 1201-9. Available for Free

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Other resources

PTSD Treatment For Monks

In this radio interview by Fresh Air, "Dr. Michael Grodin discusses his experiences treating Tibetan monks who suffer from post traumatic stress disorder. Many of the monks were imprisoned or tortured because of their resistance to the Chinese presence in Tibet, and now some of them experience "flashbacks" while meditating.

"Grodin hypothesizes that meditation may reduce the brain's ability to inhibit unpleasant thoughts and memories. His treatment combines elements of Western and Tibetan medicine and therapy. Grodin wrote about his findings in the March issue of Mental Health, Religion, and